de Sousa stratification associates patients with three distinguished colon cancer subtypes (CCS) CCS1, CCS2 and CCS3. CCS1 patients have the lowest risk of recurrence after tumour resection compared to patients belonging to the other subtypes. Interestingly, IL-1R1 overexpression is associated with more aggressive subtypes
The IL-1R1 story is getting interesting! We just published our latest finding on the role of the IL-1 pathway in the development of resistance to EGFR therapy. Exciting elements need to be uncovered.. we are working on it. Stay tuned!
